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The TRANSFOG project aims at the systematic identification and functional characterization
of novel cancer genes with high potential diagnostic and therapeutic value in breast,
colon and lung cancer. The TRANSFOG partner will bring together world recognised
competences and resources to reach the integrated research objectives.
TRANSFOG aims at the systematic identification and functional characterization of novel cancer genes
with high potential diagnostic and therapeutic value. The main ambition of this project is to re-establish
European leadership in the field of cancer genomics. To this aim, the project is integrating academic and
industrial cutting edge groups to develop a joint effort towards systematic identification and functional
characterization of novel cancer genes with high potential diagnostic and therapeutic value in breast, colon
and lung cancer. The project is based on the scientific excellence of the applicants, who have made major
recognized contributions to the field and on the construction of shared technological platforms.(...)
TRANSFOG brings together world-recognised competences and resources to reach the following, integrated research objectives:
1 Identification of novel cancer-related genes of high clinical-diagnostic potential,
with a specific focus on progression and metastasis of colon, breast, lung cancer.
2 Set-up of technologies for systematic cancer gene functional analysis and identification
of new molecular targets.
3 Systematic exploration of oncogenic/antioncogenic signalling pathways, epigenetic regulatory
mechanisms to generate a comprehensive overview of the alterations in signalling and regulatory
networks involved in cancer progression.
4 Development of tools for diagnostic validation of molecular signatures for cancers of high
population impact, such as colon, breast and lung. This enables translation into clinical
use of signatures obtained through the cancer-oriented genomic screenings performed by
the Partners.
5 Establishment of a shared bioinformatic platform for functional oncogenomics data
handling and standardization.
The TRANSFOG experimental pipeline consists of seven research components that
synergistically enable streamlined translation of large-scale genomic screenings into highimpact
contributions to cancer diagnosis and therapy.
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Piperska/ OECI Initiative
Berlin, Germany - February 18, 2010
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Cellular Oncology - New insights leading to clinical advancement
ISCO 2010 Congress - March 17-19 2010 - Dresden, Germany
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OECI General Assembly June 17th 2010, Budapest, Hungary.
OECI Scientific Conference June 18th 2010, Budapest, Hungary.
Molecular and Epidemiological Approaches to Cancer Control
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